For spotlight I just like the idea that it will rebuild the index clean after a restore. I routinely run Onyx anyway to rebuild it. That one is not strictly that important, its not a big file anyway. But in my mind it doesn't hurt to just exclude the spotlight DB and let it rebuild when I boot first time.
The Mail I really wish I could exclude now cleanly, but I don't know how. Its 30% of my backup data now.
The Caches I think why not? The other day JungleDisk left 15GB of "crap" in the caches dir, it was just some kind of failed error report image or something which I really don't want on my backup. It doubled the size of my backup. so then I started thinking to myself there are utilities to empty the cache dirs, why not just exclude them. Cache data is more or less temporary in nature most of the time. Not sure about Jungle Disk. I'm taking that off the computer though, I'll only use it from the windows machine probably.
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