SMB/CIFS or NFS for NAS Device

[dnanian]

CIFS and NFS are both protocols, not volumes. Most SMB and NFS implementations support large files. However, the big deal is the underlying volume format. If the volume doesn't support large files, it can' tbe used.

I don't know what the WD NetCenter uses, so it's hard for me to indicate whether or not it'll work. I can certainly tell you that it's likely to be quite slow, and you'll want to use SMB in most cases.

You can't use SuperDuper! 2 until you update to at least 10.3.9. I'd suggest Tiger which is faster and more reliable in general.