Well, isolating the OS by using a Sandbox will generally prevent that from happening, since the "pristine" copy of the OS remains that way on the main drive.
But it's important to remember that reinstalling a clean OS is relatively easy: you just archive-and-install. Or, you can clean install a whole copy onto a new drive, and then migrate your files, settings and apps from the original drive.
So... I don't think this is really something to worry about. Hope that makes sense!
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--Dave Nanian
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