Both source and destination grayed out
 

I have an 1.25 GHz eMac (OSX 10.5.6) that was using SD for many a year. I don't think anything changed, possibly an OSX security update?

Now both source and destination are grayed out and SD locks up. I am a registered user and have loved SD as it has saved my cheese twice!

I tried removing all files, folders, plist file and reinstalled SD w/ no result.

Sadly, now I can't use it...

Any help would be most grateful.

Did you restart your Mac? If that didn't help, remove the "Saved Settings" folder in Library/Application Support/SuperDuper! (off your Home folder).